Fumaric acid salt of 9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one, its use as a medicament and the preparation thereof

US9309228B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Markus Ostermeier · Biberach an der Riß, DE
• Peter Sieger · Mittelbiberach, DE

Key dates

• Filing date: Jul 17, 2013
• Grant date: Apr 12, 2016
• Expiry date: Jul 25, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C57/15
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a compound of formula (I),which has valuable pharmacological properties, particularly an inhibiting effect on signal transduction mediated by tyrosine kinases, processes for stereoselectively preparing these compounds, particularly pharmaceutical formulations suitable for inhalation and their use for the treatment of diseases, particularly tumoral diseases, benign prostatic hyperplasia and diseases of the lungs and airways.