Process for N-dealkylation of tertiary amines
US9309258B2 · kind B2 · utility
4Cited by
70References
37Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 2, 2014 |
| Grant date | Apr 12, 2016 |
| Priority date | — |
| Expiry date | Dec 2, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D489/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present disclosure provides improved methods for N-dealkylation of tertiary amines, including methods for N-demethylation of alkaloids and opioids, in which the dealkylation reaction is carried out in a solvent comprising a tertiary alcohol. The present disclosure also provides improved processes for preparing semi-synthetic opioids that incorporate the disclosed methods for N-dealkylation of tertiary amines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.