Patent · US Active

Protease-resistant systems for polypeptide display and methods of making and using thereof

US9309510B2 · kind B2 · utility

23Cited by

15References

37Claims

0Family size

Assignee

CytomX Therapeutics, Inc. · US

Inventors

Sherry Lynn La Porte · Horsham, US
Stephen Moore · Las Vegas, US
James William West · Lompoc, US

Key dates

Filing date	Aug 9, 2013
Grant date	Apr 12, 2016
Priority date	—
Expiry date	Aug 9, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC40B40/02
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention generally relates to bacterial polypeptide display systems, libraries using these bacterial display systems, and methods of making and using these systems, including methods for improved display of polypeptides on the extracellular surface of bacteria using circularly permuted transmembrane bacterial polypeptides that have been modified to increase resistance to protease degradation and to enhance polypeptide display characteristics.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.