Genetically modified rat models for severe combined immunodeficiency (SCID)
US9314005B2 · kind B2 · utility
6Cited by
18References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 1, 2010 |
| Grant date | Apr 19, 2016 |
| Priority date | — |
| Expiry date | Jul 1, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2015/8536
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of tumor suppressor gene(s) or gene product(s). In another aspect, the invention relates to genetically modified rats, as well as the descendants and ancestors of such animals, which are animal models of human cancer and methods of their use.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.