Compositions and methods for the storage of red blood cells
US9314014B2 · kind B2 · utility
0Cited by
16References
39Claims
0Family size
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Key dates
| Filing date | Feb 17, 2005 |
| Grant date | Apr 19, 2016 |
| Priority date | — |
| Expiry date | Nov 19, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N5/0641
- WIPO fieldBasic materials chemistry
- WIPO sectorChemistry
Abstract
The present invention provides an aqueous composition for storage of red blood cells consisting essentially of: adenine; dextrose; at least one non-metabolizable membrane-protectant sugar; and a specifically defined pH buffering system. Also provided are improved methods for preserving red blood cells and methods for increasing the viability, membrane retention, and recoverability while suppressing apoptosis, hemolysis, and post-reinfusion clearance of stored red blood cells which utilize the novel compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.