Methods of preparing pharmaceutical solid state forms
US9314471B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 17, 2013 |
| Grant date | Apr 19, 2016 |
| Priority date | — |
| Expiry date | Nov 7, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J7/0005
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides and describes solid state 17α-ethynyl-5α-androstane-3α,17β-diol including amorphous and crystalline forms and specific polymorphic forms thereof. Anhydrates and solvates of 17α-ethynyl-5α-androstane-3α,17β-diol include Form III anhydrate and Form I solvate. The invention further relates to solid and suspension formulations containing 17α-ethynyl-5α-androstane-3α,17β-diol in a described solid state form and use of the formulations to treat cancers or precancers such as prostate cancer or breast cancer in subjects or human patients. The invention also relates to methods to make liquid formulations from solid state forms of 17α-ethynyl-5α-androstane-3α,17β-diol and uses of such formulations in treating the described conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.