Preparative regimen for engraftment, growth and differentiation of non-hematopoeitic cells in vivo after transplantation
US9314486B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Sep 24, 2012 |
| Grant date | Apr 19, 2016 |
| Priority date | — |
| Expiry date | Mar 1, 2033 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are methods of obtaining an expanded population of mammalian ex vivo cells for treating a mammalian subject by (a) administering to a subject an effective amount of an agent that confers a growth disadvantage to at least a subset of endogenous cells at the site of engraftment; (b) administering to the subject an effective amount of a mitogenic stimulus for the ex vivo cells; and (c) administering the ex vivo cells to the subject, wherein the ex vivo cells engraft at the site and proliferate to a greater extent than the subset of endogenous cells, to repopulate at least a portion of the engraftment site with the ex vivo cells. The repopulated cells can be harvested or left at the engraftment site. Methods of treating brain injury in a subject by engrafting ex vivo cells at the site of injury are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.