Photostable AIE luminogens for specific mitochondrial imaging and its method of manufacturing thereof

US9315465B2 · kind B2 · utility

Assignee

• The Hong Kong University of Science and Technology

Inventors

• Benzhong Tang · Hong Kong, CN
• Yuning Hong · Hong Kong, CN
• Sijie Chen · Hong Kong, CN
• Wai Tung Leung · Hong Kong, CN
• Engui Zhao · Hong Kong, CN
• Haiqin Deng · Hong Kong, CN

Key dates

• Filing date: Jan 27, 2014
• Grant date: Apr 19, 2016
• Expiry date: Feb 4, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/52
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

AIE (aggregation-induced emission)-active TPE derivatives, TPE-TPP, TPE-MitoR and TPE-IQ are contemplated. These specific TPE derivatives are useful as fluorescent agents for mitochondrial imaging and as apoptosis inducers. Possessing high specificity to mitochondria, superior photostability and appreciable tolerance to microenvironment change, TPE derivatives are well-suited imaging agents for mitochondrial targeting and morphological change tracking. Because of their synthetic flexibility, TPE derivatives can be further modified as dual-functional probes for an array of applications such as sensing of ROS, metal ions, or pH change in mitochondria.