1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
US9315472B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 1, 2014 |
| Grant date | Apr 19, 2016 |
| Priority date | — |
| Expiry date | May 1, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/713
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides novel 1,3,5-triazinane-2,4,6-trione derivatives, such as compounds of any one of Formulae (I) and (II), and salts thereof, and methods of preparing the compounds. Also provided are compositions including a compound of the invention and an agent (e.g., an siRNA, mRNA, or plasmid DNA). The present invention also provides methods and kits using the compositions for delivering an agent to a subject (e.g., to the liver, spleen, or lung of the subject) or cell and for treating and/or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, and lung diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.