Preparation of 4-((6BR,10AS)-3-methyl-2,3,6B,9,10, 10A-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo [1,2,3-de]quinoxalin-8-(7H)-yl)-1-(4-fluorophenyl)-1-butanone or a pharmaceutically acceptable salt thereof

US9315504B2 · kind B2 · utility

Assignee

• INTRA-CELLULAR THERAPIES, INC. · US

Inventors

• John Charles Tomesch · Succasunna, US
• Peng Li · New York, US
• Wei Yao · Shanghai, CN
• Qiang Zhang · Dalian, CN
• James David Beard · New York, US
• Andrew S. Thompson · Mountainside, US
• Hua Cheng · Plainsboro, US
• Lawrence P. Wennogle · Fryeburg, US

Key dates

• Filing date: Jul 3, 2014
• Grant date: Apr 19, 2016
• Expiry date: Jul 3, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides methods for the preparation of 4-(3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido-[3′,4′:4,5]-pyrrolo[1,2,3-de]quinoxalin-8-(7H)-yl)-1-(4-fluorophenyl)-1-butanone in free form or a salt thereof.