18F-labelled folates
US9315506B2 · kind B2 · utility
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2References
26Claims
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Assignee
Inventors
Key dates
| Filing date | Apr 11, 2008 |
| Grant date | Apr 19, 2016 |
| Priority date | — |
| Expiry date | Jul 1, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/705
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein the fluorine-18 is covalently linked to the aminobenzoyl moiety, which connects the condensed pyrimidine heterocycle to the amino acid portion within folate structures, as well as their precursors and their non-radioactive references, a method of their preparation, as well as their use in diagnosis of a cell or population of cells expressing a folate-receptor and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.