Compounds as HIF-1alphainhibitors and manufacturing process thereof
US9315507B2 · kind B2 · utility
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3Claims
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Key dates
| Filing date | Sep 27, 2012 |
| Grant date | Apr 19, 2016 |
| Priority date | — |
| Expiry date | Sep 27, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/46
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to novel compounds as HIF-1α inhibitors, manufacturing process thereof, and a pharmaceutical compositions. The compounds according to the present invention having inhibition activity against HIF-1α, can be used as a therapeutic prevention and/or treatment for various solid cancers such as colon cancer, liver cancer, stomach cancer and breast cancer. Also, the compounds according to the present invention are useful in the treatment of diabetic retinopathy and rheumatoid arthritis, which are aggravated by HIF-1α-mediated VEGFA expression.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.