Tyrosine based linkers for the releasable connection of peptides

US9315543B2 · kind B2 · utility

Assignees

• Bayer Intellectual Property GmbH · DE
• Bayer Pharma Aktiengesellschaft · DE

Inventors

• Ingo Flamme · Bergneustadt, DE
• Johannes Köbberling · Neuss, DE
• Hans-Georg Lerchen · Leverkusen, DE
• Nils Griebenow · Milford, US
• Rudolf Schohe-Loop · Wuppertal, DE
• Sven Wittrock · Berlin, DE
• Ursula Krenz · Leichlingen, DE

Key dates

• Filing date: Oct 29, 2012
• Grant date: Apr 19, 2016
• Expiry date: Oct 29, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/06086
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel tyrosine based linkers that allow the releasable connection of peptides or proteins with other molecular entities, e.g. polyethylene glycol, to processes for their preparation and their use for preparing medicaments for the treatment and/or prophylaxis of diseases.