Patent · US Active

Use of interleukin 10 mRNA transfected macrophages in anti-inflammatory therapies

US9315558B2 · kind B2 · utility

0Cited by

1References

7Claims

0Family size

Assignees

RUPRECHT - KARLS - UNIVERSITÄT HEIDELBERG · DE
Universität Ulm · DE

Inventors

Ziya Kaya · Heidelberg, DE
Hugo Katus · Heidelberg, DE
Oliver Zimmermann · Waltenhofen, DE
Wolfgang Rottbauer · Ulm, DE
Jan Torzewski · Immenstadt im Allgäu, DE

Key dates

Filing date	Nov 14, 2011
Grant date	Apr 19, 2016
Priority date	—
Expiry date	Nov 21, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2510/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to the field of cell-based therapeutics. Specifically, the invention is concerned with a composition comprising a macrophage overexpressing interleukin 10 (IL-10) from transfected IL-10 encoding mRNA for use as a medicament. Moreover, a method for manufacturing a medicament for treating and/or preventing inflammation or a disease or disorder associated therewith comprising the steps of obtaining a macrophage from a sample of said subject, transfecting mRNA encoding IL-10 into said macrophage, and formulating said macrophage in a composition suitable for administration to the said subject, whereby the medicament is manufactured. Finally, a kit is provided for manufacturing such a medicament.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.