LH-type bispecific antibody
US9315584B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 4, 2010 |
| Grant date | Apr 19, 2016 |
| Priority date | — |
| Expiry date | Feb 13, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/626
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided are a novel diabody type bispecific antibody, the function of which as a bispecific antibody is improved to provide a higher additional value, such as cost saving caused by a reduction in dose, to a drug; and a method for producing the same. A humanized diabody type bispecific antibody (LH-diabody type bispecific antibody) characterized in that an L-chain is located in the N-terminal side in each polypeptide (LH type); a humanized high-functional bispecific antibody which contains said LH diabody type bispecific antibody; a nucleic acid molecule encoding both of two kinds of single-stranded polypeptides constituting said bispecific antibody; and a method for producing said antibody which comprises culturing a host cell having been transformed by an expression vector containing said nucleic acid molecule.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.