Nucleic acids containing a synthetic codon-optimized Sin Nombre virus full-length M gene

US9315826B2 · kind B2 · utility

Assignee

• The United States of America as rep. by the Sec'y of the Army, for U.S. Army Medical Research Institute of Infectious Diseases · US

Inventor

• Jay Hooper · New Market, US

Key dates

• Filing date: Jan 31, 2011
• Grant date: Apr 19, 2016
• Expiry date: Jan 31, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/12171
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention contemplates a new synthetic, codon-optimized Sin Nombre virus (SNV) full-length M gene open reading frame (ORF) that encodes a unique consensus amino acid sequence. The SNV ORF was cloned into a plasmid to form the first stable recombinant SNV full-length M gene that elicits neutralizing antibodies. The gene can be engineered into a vaccine system, and is useful to protect mammals against infection with Sin Nombre virus.