Peptide tyrosinase inhibitors and uses thereof
US9320698B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 10, 2012 |
| Grant date | Apr 26, 2016 |
| Priority date | — |
| Expiry date | May 10, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2800/82
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are peptides that inhibit the enzymatic activity of tyrosinase, as well as formulations and methods for their use in the reduction of skin pigmentation, and methods of administering the inhibitory pep tides in a topical formulation. Preferred octapeptide sequences are internally rich in tryptophan and/or tyrosine or arginine. The present invention is further directed to kits and compositions containing the present peptides, and methods of treatment of conditions involving expression of tyrosinase, in which the present peptides are administered topically for the treatment of conditions involving melanocyte activity in the skin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.