Methods and compositions for CNS delivery of heparan N-sulfatase
US9320711B2 · kind B2 · utility
18Cited by
12References
43Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 25, 2011 |
| Grant date | Apr 26, 2016 |
| Priority date | — |
| Expiry date | Jan 11, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/0019
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising a heparan N-sulfatase (HNS) protein, salt, and a polysorbate surfactant for the treatment of Sanfilippo Syndrome Type A.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.