Regulators of aldehyde dehydrogenase ALDH3A1 and related therapeutic methods
US9320722B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Sep 26, 2014 |
| Grant date | Apr 26, 2016 |
| Priority date | — |
| Expiry date | Sep 26, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are compositions and methods for the treatment of cancer, and in particular cancers characterized by a high level of ALD3H1 activity, which is associated with chemoresistance to cancer chemotherapeutic agents that are degraded by ALD3H1. The compositions described herein act as competitive inhibitors of ALD3H1 and thereby reduce breakdown of chemotherapeutics by this enzyme, and increase their efficacy for cancer treatment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.