Patent · US Active

Therapeutic and diagnostic molecules

US9320755B2 · kind B2 · utility

0Cited by

0References

9Claims

0Family size

Assignees

CENTENARY INSTITUTE OF CANCER MEDICINE AND CELL BIOLOGY · AU
The University of Sydney · AU
WENKART FOUNDATION · AU

Inventors

Jennifer Gamble · Sydney, AU
Mathew Vadas · Pimba, AU
Gregory Goodall · Netherby, AU
Jennifer Young · Los Alamos, US

Key dates

Filing date	Jun 4, 2010
Grant date	Apr 26, 2016
Priority date	—
Expiry date	Aug 26, 2030

Classification

Technology area (CPC G)Physics
CPC primaryG01N2800/7014
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to methods for modulating angiogenesis, comprising administering to a subject, or cells or tissue derived therefrom: (i) one or more miRNA, or precursors or variants thereof, wherein at least one of said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to inhibit angiogenesis; or (ii) one or more antagonists of a miRNA, wherein said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to promote or induce angiogenesis. Also provided are methods of diagnosis of conditions associated with abnormal angiogenesis, or determining predisposition thereto. Suitable pharmaceutical compositions are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.