Tissue targeted antigenic activation of the immune response to treat cancers
US9320788B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jun 20, 2013 |
| Grant date | Apr 26, 2016 |
| Priority date | — |
| Expiry date | Mar 8, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/31
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides in part methods of treating cancers of a specific organ or tissue by administering a composition that is antigenically specific for one or more microbes that are pathogenic in the specific organ or tissue in which the cancer is situated. The formulations of the invention thereby facilitate activation of an immune response to a cancer in a particular tissue or organ. The compositions may for example include killed or attenuated microbial pathogens, such as whole killed bacterial cells, and may be administered at sites distant from the cancer, for example the skin. In some embodiments, microbial species of endogenous flora or exogenous microbial pathogens that are known to cause infection in the relevant organ or tissue may be used in the formulation of the antigenic compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.