Patent · US Active

Azole compounds as PIM inhibitors

US9321756B2 · kind B2 · utility

0Cited by

6References

16Claims

0Family size

Assignee

AMGEN INC. · US

Inventors

Hui-Ling Wang · Thousand Oaks, US
Victor J. Cee · Thousand Oaks, US
Bradley J. Herberich · Newbury Park, US
Claire L. M. Jackson · Thousand Oaks, US
Brian Alan LANMAN · Calabasas, US
Thomas Nixey · Newbury Park, US
Liping H. Pettus · Thousand Oaks, US
Anthony B. Reed · Newbury Park, US
Bin Wu · Thousand Oaks, US
Ryan Wurz · Newbury Park, US
Andrew Tasker · Simi Valley, US

Key dates

Filing date	Mar 21, 2012
Grant date	Apr 26, 2016
Priority date	—
Expiry date	Jun 12, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D487/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to bicyclic compounds of formulas I and Ia, and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.