Phosphoramidite derivatives of gemcitabine for use in the treatment of cancer
US9321798B2 · kind B2 · utility
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7References
27Claims
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Key dates
| Filing date | Oct 5, 2011 |
| Grant date | Apr 26, 2016 |
| Priority date | — |
| Expiry date | May 3, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Phosphorodiamidate derivatives of e.g. gemcitabine are provided for use in treating cancer. In one embodiment, the two amidate motifs each comprises NR′R″ where R′ is H and R″ is CR5R6CO2R7, where R6 is H, R5 is the side chain, including H and C1, of a naturally occurring alpha amino acid, and R7 is branched or unbranched, substituted or unsubstituted, acyclic or cyclic alkyl, including t-butyl-CH2-, benzyl and C3 to C6 cycloalkyl. Formula (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.