Homo- and heterodimeric SMAC mimetic compounds as apoptosis inducers
US9321808B2 · kind B2 · utility
22Cited by
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16Claims
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Key dates
| Filing date | Feb 20, 2012 |
| Grant date | Apr 26, 2016 |
| Priority date | — |
| Expiry date | Feb 20, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to conformationally constrained homo- and heterodimeric mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.