Methods and compositions for cytomegalovirus IL-10 protein
US9321813B2 · kind B2 · utility
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5Claims
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Key dates
| Filing date | Mar 27, 2012 |
| Grant date | Apr 26, 2016 |
| Priority date | — |
| Expiry date | Mar 27, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/16162
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods and compositions for treating and/or preventing a cytomegalovirus infection in a subject, comprising administering to the subject an effective amount of a cytomegalovirus interleukin-10 (IL-10) protein modified to have reduced functional activity while retaining immunogenicity. The present invention further provides nucleic acid molecules encoding a cytomegalovirus IL-10 protein or fragment thereof of this invention as well as vectors comprising such nucleic acids. Also provided herein are neutralizing antibodies that specifically bind cmvIL-10.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.