Patent · US Active

Inhibition of DNA2 in fanconi anemia

US9322022B2 · kind B2 · utility

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7Claims

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Assignee

CALIFORNIA INSTITUTE OF TECHNOLOGY · US

Inventors

Kenneth Karanja · Maple Grove, US
Martin E. Budd · Pasadena, US
Judith Campbell · Sierra Madre, US

Key dates

Filing date	Oct 21, 2014
Grant date	Apr 26, 2016
Priority date	—
Expiry date	Oct 21, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y306/04012
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Inhibition of DNA2 in Fanconi anemia (FA) cells remedies the over-resection of DNA, thereby stabilizing the FA cells. Inhibition of DNA2 in FA cells allows for safe treatment of cancers in FA patients, a decrease in the lethality of FA cells, a decrease in bone marrow failure of FA patients, and a means for decreasing the incidence of cancer for FA patients.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.