Methods of and devices for capturing circulating tumor cells

US9322047B2 · kind B2 · utility

Assignee

• BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE · US

Inventors

• Taehyun Park · Seoul, KR
• Daniel Sang-Won Park · Baton Rouge, US
• Sudheer D. Rani · Baton Rouge, US
• Michael C. Murphy · Baton Rouge, US
• Dimitris E. Nikitopoulos · Baton Rouge, US

Key dates

• Filing date: Oct 19, 2012
• Grant date: Apr 26, 2016
• Expiry date: Oct 19, 2032

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01L2400/0487
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A device and methods are provided for efficient and quick capture of target cells through a main microchannel having capture elements immobilized thereon and manipulating a velocity profile of a sample as it passes through the main microchannel. The cell capture device may have a main microchannel with a depth slightly larger than the diameter of the target cells and a plurality of side microchannels. The side microchannels may have a depth smaller than the diameter of the target cells. The device and methods may be used for early cancer detection.