Multiple sample chromatography using a stochastic injection technique

US9322812B2 · kind B2 · utility

Assignees

• INSTITUT FRANÇAIS DES SCIENCES ET TECHNOLOGIES DES TRANSPORTS DE L'AMENAGEMENT ET DES RESEAUX (IFSTTAR) · FR
• Chambre de Commerce et D'Industrie de Region Paris Ile de France (ESIEE Paris) · FR

Inventors

• Dan Angelescu · Cambridge, US
• William Cesar · Paris, FR
• Tarik E. Bourouina · Alice Street, FR

Key dates

• Filing date: Jan 17, 2014
• Grant date: Apr 26, 2016
• Expiry date: Oct 20, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N30/86
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention relates to a method for simultaneously analyzing at least two samples using a chromatography device comprising a chromatography column having an inlet and an outlet, and at least one detector placed at the outlet of the chromatography column, the method comprising steps of: injecting fractions of each independent sample at the inlet of the chromatography column, the fractions of each independent sample being injected according to a specific injection timing sequence derived from a pseudo-random binary sequence associated with said independent sample; recording a signal generated by said detector for a period of time at least equal to a duration of the longest of the specific injection timing sequences; cross-correlating the recorded signal and a derived correlation function, said derived correlation function being derived from the pseudo-random binary sequence associated with one of the independent samples, so as to obtain an individual correlogram signal specific to said independent sample; and analyzing data of interest of the individual correlogram signal so as to obtain an output signal indicative of a composition of the sample.