Selective androgen receptor modulators

US9328104B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• James Thomas Anderson · Hillsdale, US
• Eugene Lvovich Piatnitski Chekler · Concord, US
• Edmund Lee Ellsworth · Brighton, US
• Bruce Kipp Erickson · Kalamazoo, US
• Adam Matthew Gilbert · Congers, US
• Anthony Ricketts · Stonington, US
• David P. Thompson · Battle Creek, US
• Rayomand Jal Unwalla · Eagleville, US
• Patrick Robert Verhoest · Newton, US

Key dates

• Filing date: Dec 2, 2013
• Grant date: May 3, 2016
• Expiry date: May 29, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a compound of Formula 1, 2 or 3:wherein A is N or —CR0—, where R0 is hydrogen, C1-C6 linear or branched chain alkyl, etc., Z is —CRe—, or, —N—, where Re is hydrogen, C1-C6 linear or branched chain alkyl, etc.; R1 is hydrogen, C1-C6 linear or branched chain alkyl, etc.; R2 are independently hydrogen or C1-C6 linear or branched chain alkyl; R3 and R4 are independently hydrogen, C1-C6 linear or branched chain alkyl, etc.; R5 and R6 are independently hydrogen or C1-C6 linear or branched chain alkyl, etc.; R8 is hydrogen, C1-C6 linear or branched chain alkyl, etc.; R9 and R10 are independently hydrogen or C1-C6 linear or branched chain alkyl, etc.; Q is —CO—, —(CH2)q—, —(CHRs)q—, or —(CRsRt)q—, where Rs and Rt are independently C1-C6 linear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl; where q is 0, 1, 2, or 3; and, where n is 0, 1, 2, 3, 4 or 5; or, a pharmaceutically acceptable salt thereof, to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly, those affected or mediated by the androgen receptor.