Rotenone derivatives and a use thereof
US9328123B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 22, 2015 |
| Grant date | May 3, 2016 |
| Priority date | — |
| Expiry date | Apr 22, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/20
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to rotenone derivatives and a use of the same. Particularly, the present inventors identified rotenoisin A and B which are compounds with no toxicity and which are prepared by irradiation with gamma rays onto rotenone as represented by the following formula 1. It was further confirmed that the rotenone derivatives significantly inhibited pancreatic lipase activity and preadipocyte differentiation. The rotenone derivatives of the present invention can be effectively used as a composition for the prevention and treatment of obesity and as a composition for health functional food for the prevention and improvement of obesity:(In formula 1, R1 and R2 are as defined in this description).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.