Compositions of asymmetric interfering RNA and uses thereof
US9328345B2 · kind B2 · utility
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31Claims
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Key dates
| Filing date | Aug 27, 2008 |
| Grant date | May 3, 2016 |
| Priority date | — |
| Expiry date | Feb 25, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2330/51
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides asymmetrical duplex RNA molecules that are capable of effecting sequence-specific gene silencing. The RNA molecule comprises a first strand and a second strand. The first strand is longer than the second strand. The RNA molecule comprises a double-stranded region formed by the first strand and the second strand, and two ends independently selected from the group consisting of 5′-overhang, 3′-overhang, and blunt end. The RNA molecules of the present invention can be used as research tools and/or therapeutics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.