Patent · US Active

Polymer-coupled peptidases

US9329192B2 · kind B2 · utility

1Cited by

2References

25Claims

0Family size

Assignee

SENOVA GESELLSCHAFT FUR BIOWISSENSCHAFT UND TECHNIK MBH · DE

Inventors

Hans-Jurgen Kolde · Marburg, DE
Ute Lange · Kahla, DE
Elke Bucha · Erfurt, DE

Key dates

Filing date	Feb 14, 2011
Grant date	May 3, 2016
Priority date	—
Expiry date	Nov 10, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y304/21005
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention is directed to a simple process for the modification of the specificity of a peptidase of the hemostatic system by coupling polymers to the peptidase causing it to lose its reactivity in the hemostatic system, but enabling it to continue to react with certain inhibitors, effectors and substrates. The invention is furthermore directed to processes for the detection or quantitative determination of inhibitors of the peptidase in bodily fluids or other samples as well as to processes for their neutralization and/or removal from liquids. Finally, the invention allows the use of a polymer-coupled peptidase as drug and furthermore provides a device which makes use of such a peptidase in the removal of peptidase inhibitors from samples or from the bloodstream of a patient.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.