Devices and systems for elution of biomolecules

US9333463B2 · kind B2 · utility

Assignee

• General Electric Company · US

Inventors

• Christopher Michael Puleo · Niskayuna, US
• John Richard Nelson · Fryeburg, US
• Patrick McCoy Spooner · Slingerlands, US
• Ralf Lenigk · Niskayuna, US
• Nichole Lea Wood · Niskayuna, US
• Li Zhu · San Jose, US
• Craig Patrick Galligan · Niskayuna, US

Key dates

• Filing date: Jul 26, 2013
• Grant date: May 10, 2016
• Expiry date: Nov 24, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N27/4473
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

A device and a system for eluting biomolecules from biological sample by electroelution are provided. The device for electroelution of biomolecules from a biological sample is constituted with a housing configured to receive an electrolyte and the biological sample, at least two electrodes comprising conductive redox polymers operationally coupled to the housing, and a biomolecule impermeable layer disposed on at least one of the electrodes. The biomolecule impermeable layer disposed on at least one of the electrodes to prevent the biomolecules from reaching the electrode. A system is provided, wherein the system comprises a sample collection port, one or more reservoirs comprising a buffer, a solvent, a reagent or combinations thereof, an device for electroelution, and a controller.