Minor groove binder (MGB)-oligonucleotide miRNA antagonists

US9334495B2 · kind B2 · utility

Assignee

• ELITECHGROUP B.V. · NL

Inventors

• Anastasia Khvorova · Boulder, US
• Annaleen Vermeulen · Lafayette, US
• Rob Kaiser · Broomfield, US
• Jon Karpilow · Boulder, US
• Nicolaas M. J. Vermeulen · Woodinville, US
• Walt Mahoney · Woodinville, US

Key dates

• Filing date: Nov 23, 2010
• Grant date: May 10, 2016
• Expiry date: Nov 23, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/351
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions and methods for inhibiting the actions of non-coding RNAs such as miRNAs and piRNAs are provided. The compositions comprise single or double stranded oligonucleotides conjugated with Minor Groove Binders (“MGBs”). The oligonucleotides can vary in length, can contain nucleotides having one or more modifications, and have regions that are substantially complementary to one or more mature miRNAs or piRNAs.