Glucose-responsive microgels for closed loop insulin delivery
US9339529B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Feb 19, 2013 |
| Grant date | May 17, 2016 |
| Priority date | — |
| Expiry date | Feb 19, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y111/01006
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Injectable insulin loaded microgels that are capable of modifying the amount of insulin released based on the patient's tissue glucose levels, methods for making and using these compositions have been developed. The microgels contain insulin, glucose oxidase entrapped in or bound to the microgels, and an agent that reduces hydrogen peroxide, entrapped in or bound to the microgels, wherein the polymeric microgel expands when pH decreases from physiological pH and shrinks when pH increases towards physiological pH, thereby releasing insulin at a rate corresponding to the glucose concentration. In one embodiment, the glucose oxidase and/or the agent reducing hydrogen peroxide are encapsulated in nanogels, then encapsulated within the microgel.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.