Meta-Diarylaniline or meta-diarylpyridinamine compound, preparation method and medical uses thereof

US9340492B2 · kind B2 · utility

Assignee

• INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES · CN

Inventors

• Lan Xie · Chapel Hill, US
• Chin-Ho Chen · Chapel Hill, US
• Lianqi Sun · Beijing, CN
• Na Liu · Jiaocheng District, CN

Key dates

• Filing date: Jul 15, 2013
• Grant date: May 17, 2016
• Expiry date: Jul 15, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Meta-diarylaniline or meta-diarylpyridinamine compounds, methods for preparing the same and uses thereof in manufacture of a medicament. The compounds according to the present application have strong inhibitory activity (at nM level) against wild-type and various drug-resistant HIV viral strains, exhibit good druggability, and can be easily synthesized.