Hydroxamic acid derivatives useful as antibacterial agents

US9340493B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• Matthew Frank Brown · Stonington, US
• Charles Francis Donovan · Colchester, US
• Edmund Lee Ellsworth · Brighton, US
• Denton W. Hoyer · West Haven, US
• Timothy Allan Johnson · Richland, US
• Manjinder Singh Lall · East Lyme, US
• Chris Limberakis · Pawcatuck, US
• Sean Murphy · San Diego, US
• Debra Ann Sherry · Chelsea, US
• Clarke B. Taylor · Ann Arbor, US
• Joseph Scott Warmus · Ann Arbor, US

Key dates

• Filing date: Mar 24, 2014
• Grant date: May 17, 2016
• Expiry date: Mar 24, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a compound of formula (I):or a pharmaceutically acceptable salt thereof, thereof, wherein: and pharmaceutically acceptable salts, prodrugs, hydrates, or solvates, thereof, wherein A, B, L1-L4, A, B, R1-R4, and m are as defined herein. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and their use in treating a bacterial infection.