Multicomponent crystals comprising dasatinib and selected co-crystal formers

US9340536B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Tiziana Chiodo · Mannheim, DE
• Andreas Hafner · Gelterkinden, CH
• Tobias Hintermann · Therwil, CH
• Beate Salvador · Ellerstadt, DE
• Martin Szelagiewicz · Münchenstein, CH
• Fritz Blatter · Reinach, CH
• Bernd Siebenhaar · Kandern, DE
• Marcus Vossen · Schifferstadt, DE

Key dates

• Filing date: Jun 13, 2013
• Grant date: May 17, 2016
• Expiry date: Jun 13, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are a multicomponent crystalline system (co-crystal), use thereof, as well as a process for obtaining the same. The said multicomponent crystalline system (co-crystal) comprises Dasatinib and a second compound selected from methyM-hydrobenzoate, nicotinamide, ethyl gallate, methyl gallate, propyl gallate, ethyl maltol, vanillin, menthol, or (1R,2S,5R)-(−)-menthol.