Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
US9340550B2 · kind B2 · utility
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36Claims
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Key dates
| Filing date | Jan 30, 2015 |
| Grant date | May 17, 2016 |
| Priority date | — |
| Expiry date | Jan 30, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D489/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a method for the N-demethylation and N-functionalization of an N-methylated heterocycle such as a morphine alkaloid or tropane alkaloid. The method comprises reacting the heterocycle with an functionalization agent in the presence of a transition metal catalyst in air or in the presence of an oxidant.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.