Patent · US Active

Specific fluorescent probe based on albumin pseudo-esterase hydrolysis reaction and use thereof

US9340821B2 · kind B2 · utility

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5Claims

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Assignee

DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES · CN

Inventors

Ling Yang · Lianyungang, CN
Jingnan Cui · Dalian, CN
Guangbo Ge · Dalian, CN
Zhaoming Liu · Beijing, CN
Lei Feng · Longbeilingcun, CN

Key dates

Filing date	Mar 27, 2014
Grant date	May 17, 2016
Priority date	—
Expiry date	Mar 27, 2034

Classification

Technology area (CPC G)Physics
CPC primaryG01N2333/765
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

A pseudo-esterase activity-based fluorescent probe for specific detection of albumin, which has a carboxylic ester bond that can be selectively cleaved by human serum albumin (HSA), therefore forming a hydrolysate, which has a fluorescence emission spectrum significantly different from that of the fluorescent probe. According to the fluorescence intensity of the fluorescent probe and hydrolysate, we can detect the content of HSA in a biological sample.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.