Macrocyclic lactone drug delivery system
US9345686B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 16, 2010 |
| Grant date | May 24, 2016 |
| Priority date | — |
| Expiry date | Oct 18, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P33/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a drug delivery system from which a macrocyclic lactone can be released with a desirable zero order release profile. The system is based on the use of thermoplastic polymers, and particularly of polyethylene vinyl acetate copolymers (EVA). The drug delivery system of the invention comprises a solid non-porous reservoir in which the macrocyclic lactone is contained, preferably in a concentration well above the saturation concentration, and a non-porous skin covering the reservoir not initially loaded with the drug. The system is preferably in the form of a rod, wherein the core and the skin are concentric, and the end surfaces of the rod are not skin-covered.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.