Compositions for targeted delivery of siRNA
US9345775B2 · kind B2 · utility
3Cited by
19References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 18, 2015 |
| Grant date | May 24, 2016 |
| Priority date | — |
| Expiry date | Mar 18, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.