Reconstituted human breast tumor model
US9345788B2 · kind B2 · utility
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5Claims
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Key dates
| Filing date | Jun 28, 2005 |
| Grant date | May 24, 2016 |
| Priority date | — |
| Expiry date | Dec 14, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2799/027
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A reconstituted human breast tumor model is disclosed. The model, which is incorporated into mice, provides actual tumors that arise spontaneously, thereby mimicking naturally occurring breast cancer. The tumors are genetically human, because they arise from human mammary tissues that develop from human mammary epithelial cells implanted into host mice. Prior to implantation, the mammary epithelial cells are genetically modified to contain a recombinant human oncogene and an SV40 early region.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.