Ligands for targeting of S1P receptors for in vivo imaging and treatment of diseases

US9345791B2 · kind B2 · utility

Assignee

• WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER · DE

Inventors

• Guenter Haufe · Munster, DE
• Bodo Levkau · Munster, DE
• Michael Schaefers · Munster, DE
• Stefani Silke Schilson · Munster, DE
• Petra Keul · Goldkronach, DE

Key dates

• Filing date: Aug 16, 2012
• Grant date: May 24, 2016
• Expiry date: Aug 16, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel compounds of formulae (I) and (II) which are useful in the prevention, treatment and diagnosis, in vivo diagnosis of diseases or disorders related to S1P receptors, in particular, in diseases which are connected to the regulatory function of sphingosine-1-phosphate (S1P) and its analogs, such as inflammation, pain, autoimmune diseases and cardiovascular diseases.