Process for producing compositions rich in crystals of mannitol in delta form, compositions and crystals obtained and uses thereof
US9346726B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 7, 2013 |
| Grant date | May 24, 2016 |
| Priority date | — |
| Expiry date | Aug 7, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C29/86
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for producing a composition which is particularly rich in D-mannitol, the latter being present in the form of crystals having a volume average diameter greater than 20 pm, wherein the crystals correspond to a very large extent to the δ polymorph. This process makes use of the evaporative crystallization technique, in which the seeding and then the controlled growth of the crystals is carried out at different evaporation rates. Finally, very pure δ crystals are advantageously obtained, which have a better compressibility than the α and β homologues thereof and which, by virtue of the sizes thereof, result in a powder which is not subject to caking.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.