Process for the preparation of treprostinil and derivatives thereof
US9346738B2 · kind B2 · utility
34Cited by
2References
17Claims
0Family size
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Key dates
| Filing date | May 22, 2013 |
| Grant date | May 24, 2016 |
| Priority date | — |
| Expiry date | May 22, 2033 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for the preparation of treprostinil and its derivatives is described. In contrast to prior art, this method utilizes an easily scalable enzymatic resolution of a key intermediate for making these compounds. Another significant improvement of the described method over prior methods is the regioselective Claisen rearrangement of a 5-allyloxy-benzaldehyde precursor, which is facilitated by a bromo substituent in 2-position.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.