Phenyl-substituted nicotinic ligands, and methods of use thereof

US9346784B2 · kind B2 · utility

Assignees

• Georgetown University · US
• Duke University · US

Inventors

• Milton L. Brown · Brookeville, US
• Mikell Paige · Fairfax, US
• Yingxian Xiao · Potomac, US
• Kenneth J. Kellar · Bethesda, US
• Venkata M. Yenugonda · McLean, US
• Edward D. Levin · Chapel Hill, US
• Amir H. Rezvani · Chapel Hill, US

Key dates

• Filing date: Nov 9, 2012
• Grant date: May 24, 2016
• Expiry date: Nov 9, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/65
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds and methods of using them to treat a disorder selected from the group consisting of addiction, pain, obesity, schizophrenia, epilepsy, mania and manic depression, anxiety, Alzheimer's disease, learning deficit, cognition deficit, attention deficit, memory loss, Lewy Body Dementia, Attention Deficit Hyperactivity Disorder (ADHD), Parkinson's disease, Huntington's disease, Tourette's syndrome, amyotrophic lateral sclerosis, inflammation, stroke, spinal cord injury, dyskinesias, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, autism, mutism, trichotillomania, hypothermia, and disorders of sleep.