Substituted sulfonamides useful as antiapoptotic Bcl inhibitors

US9346795B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Robert M. Borzilleri · Haneys Mill, US
• Zhen-Wei Cai · Montgomery, US
• Andrew J. Tebben · New Hope, US
• Heidi L. Perez · Ewing, US
• Liping Zhang · Plainsboro, US
• Gretchen M. Schroeder · Ewing, US
• Donna D. Wei · Montgomery, US

Key dates

• Filing date: May 23, 2012
• Grant date: May 24, 2016
• Expiry date: May 23, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds.