Cancer-related glycopeptide epitopes, antibodies and methods of use
US9346867B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Apr 15, 2011 |
| Grant date | May 24, 2016 |
| Priority date | — |
| Expiry date | Apr 15, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/34
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Cancer-associated O-glycopeptide combination epitopes derived from the VNTR of MUC1 are disclosed. Autoantibodies present in human sera target the combination epitopes and are reduced or absent in cancer patients. The epitopes are useful as therapeutic and immunoprophylactic cancer vaccines. Monoclonal antibodies directed against the epitopes are also useful as immunotherapeutics for treatment and prevention of cancer. Diagnostic methods using the epitopes and antibodies are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.