Process for the preparation of highly O-sulfated, epimerized derivatives of K5 polysacchride and intermediates therein
US9346893B2 · kind B2 · utility
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Key dates
| Filing date | Jul 10, 2014 |
| Grant date | May 24, 2016 |
| Priority date | — |
| Expiry date | Jul 10, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08B37/0078
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A new method is described for the oversulfation of epiK5-N-sulfate to obtain an epiK5-amine-O-oversulfate with very high sulfation degree which, by subsequent N-sulfation, provides new epiK5-N,O-oversulfate-derivatives with a sulfation degree of at least 4, basically free of activity on the coagulation parameters and useful in the cosmetic or pharmaceutical field. Also described are new low molecular weight epiK5-N-sulfates useful as intermediates in the preparation of the corresponding LMW-epiK5-N,O-oversulfate-derivatives.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.